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WAM Essentials, Inc.
Systemic Enzyme Therapy
... Allowing You to Live Your Passion!™ |
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Beneficial effect of proteases on
allograft arteriosclerosis in a rat aortic model
Gaciong Z.1,
Paczek L.1, Bojakowski
K.1, Socha K.1,
Wisniewski M.2 and Heidland
A.3
1Transplantation Institute and 2Department
of Dental Surgery, Warsaw School of Medicine, Warsaw, Poland,
and 3Department of Internal Medicine,
University of Wurzburg, Wurzburg, Germany
Nephrol Dial Transplant 1996, Vol. 11, No. 6, pp. 987-989.
SO 108 (17-09-2) |
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Abstract
Recently it has been shown that protease therapy ameliorates
certain immune-mediated diseases. Thus we studied the effect
of administration of a protease mixture on aortic transplant
arteriosclerosis in rats. Segments of abdominal aorta from
SHR strain were transplanted orthotopically into WKY recipients.
Two groups of allografted rats were used. One group (n=8)
was treated with daily intraperitoneal injections of 12 mg
of a protease formulation containing trypsin, bromelain and
rutosid, and another group (n=8) with placebo. Eight WKY
rats were transplanted with syngenic aortas and treated with
placebo. After 8 weeks, structural changes of the grafted
segment were evaluated by morphometric analysis of formalin-fixed
sections with specific stains. In untreated allografts there
was a marked intimal thickening, medial necrosis with disruption
of elastic fibres, and inflammatory infiltrates in the adventitia.
Administration of proteases inhibited formation of neointima
by 59.0% when cross-sectional areas were compared (80±11
versus 195±11 mm2, P<0.01; protease-versus placebo-treated
allograft recipients respectively) and decreased medial injury
as estimated by the integrity of elastic fibres and smooth-muscle
cell density. Thus, in an experimental model of rat aortic
allograft, protease administration ameliorates rejection-induced
arterial wall remodelling.
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