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WAM Essentials, Inc.
Systemic Enzyme Therapy
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Treatment of collagen-induced arthritis
by proteolytic enzymes. Immunomodulatory and disease-modifying
effects
Chintalacharuvu S. R., Nagy N.U., Petersilge Ch.
A., Abdul-Karim F. W., and Emancipator S.N.
From the Institute of Pathology and the Department of
Radiology, Case Western Reserve University, Cleveland,
OH USA
The Journal of Rheumatology 2001, Vol. 28, No. 9, pp 2049-2059
573 KA |
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Abstract
Objective
To investigate the efficacy of a novel therapy (proteases)
in an animal model of rheumatoid arthritis, and to gain insight
to the mechanisms of arthritogenesis.
Methods
We induced progressive arthritis in male DBA/1 mice by immunization
and boosting with Type II collagen; groups of mice were treated
orally twice daily with either ibuprofen or a commercial
cocktail of proteases, or left untreated. After two weeks,
joints were scored for clinical, radiographic and histologic
changes. In addition, serum levels of IgG anti-collagen II,
the glycosylation of circulating total and anti-collagen
II IgG, and cytokine production by lymphocytes isolated from
lymph nodes were measured.
Results
Amelioration of joint inflammation and destruction, and
accentuation of a prototypical Th2 cytokine (IL-5) were similar
in ibuprofen and protease treatment groups. However, protease
treatment protects and preserves articular cartilage, normalizes
the sialylation of IgG and anti-collagen autoantibody and
fully restores Th1 (IFN-g) synthesis. Conclusion. Protease
therapy has anti-inflammatory efficacy in collagen-induced
arthritis, similar to ibuprofen. In addition, the immunomodulatory
effects of proteases, not seen with ibuprofen, may underlie
a correction of aberrant IgG glycosylation and/or contribute
to the increased capacity of protease to delay or forestall
erosive and destructive arthritis or ankylosis. Similar effects
may apply to spontaneous RA in patients. |
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