|
WAM Essentials, Inc.
Systemic Enzyme Therapy
... Allowing You to Live Your Passion!™ |
|
|
|
|
|
|
|
Efficacy and tolerance of oral hydrolytic
enzymes in ankylosing spondylitis as compared with indomethacin:
a controlled double-blind prospective clinical trial
Baerwald CH., Willeke A., Lies S., GoebelK-M.1
1 Clinic for Rheumatic Diseases, Bad Endbach, Germany
Journal of Clinical Research 1999, Vol. 2, pp. 17-34, ISSN
1369-5207
MU 16 (3-13-1) |
|
Summary
The high prevalence of ankylosing spondylitis, the burden
of suffering patients, socio-economically relevant disability
times up to premature retirement, side-effects of present
therapies as well as first positive results of a pilot study
on the complaints encouraged us to start a randomised double-blind
clinical trial with two parallel groups.
Our aim was to compare an oral enzyme combination
preparation with indomethacin in terms of efficacy (clinical
symptoms, especially pain), tolerance and side effects. Two
groups of 20 patients were treated for six months. They were
examined clinically and questioned for efficacy and tolerance
at baseline (day of inclusion), then after one week, one
month, two, four and six months. There was a significant
difference for the Mann-Whitney statistic (95% confidence
interval 0.73 - 1.00; p<0.0001) in favour of the enzyme
group with the main criterion being the sum score of pain
items after six months. The most important descriptively
evaluated single pain data, also showed similar differences
at end of therapy. It was noticeable that indomethacin demonstrated
a marked initial improvement, which lessened afterwards,
whereas the enzyme combination showed a continuous improvement
until the end of therapy, with superiority over indomethacin.
These results permit the assumption that the tested clinical
symptoms are positively influenced by the enzymes. The merely
mild and transient adverse events with enzyme therapy suggest
that it is suitable for long-term treatment. As efficacy
becomes apparent after some time, but then substantially
better, a combination with NSAIDs might be considered during
the first two months. |
|
|
Medical Disclaimer: We believe
that the role of nutrition is important to good health, however,
this web site is for informational purposes only and is not
intended to be a substitute for professional medical advice.
Our goal is to provide you, the customer, with the information
necessary for you to make important nutritional and self-help
decisions. We strongly suggest that you share any products
you decide to use with your health care professional for optimal
individual health benefits. Women who are planning on becoming
pregnant or who are pregnant should not take any supplements
without consulting their physician first. Information and statements
on this website regarding dietary supplements have not been
evaluated by the Food and Drug Administration, and are not
intended to diagnose, treat, cure, mitigate or prevent any
disease or health condition.
|
|
|
© Copyright 2004 WAM Essentials,
Inc. All Rights Reserved.
None of the material contained herein may be reproduced without
the prior written consent of WAM Essentials, Inc. |
|
|