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WAM Essentials, Inc.
Systemic Enzyme Therapy
... Allowing You to Live Your Passion!™ |
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A new method for evaluating mucolytic expectorant activity
and its application. II. Application to two proteolytic
enzymes, serratiopeptidase and seaprose.
Kase Y, Seo H, Oyama Y, Sakata M, Tomoda K, Takahama
K, Hitoshi T, Okano Y, Miyata T.
Arzneimittelforschung. 1982;32(4):374-8.
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Using our new method described in a preceding
paper, in vivo effects of two proteolytic enzymes such as serratiopeptidase
(SER) and seaprose (SAP) on sputa collected from bronchitis
rabbits were examined. SER (20 mg/kg) and SAP (30 mg/kg) significantly
reduced the viscosity of sputum (P less than 0.05) at the 1-3-h
periods and the 4-6-h periods, respectively, after intraduodenal
administration. 50 mg/kg of SER also significantly decreased
not only viscosity (P less than 0.001) but also amount of freeze-dried
substance (P less than 0.05) of sputum at the 1-3-h periods,
but SAP did not affect the amount of dried substance. Both
enzymes significantly increased the volume of sputum, probably
as the result of liquefaction. Thus, mucolytic expectorant
activity of both enzymes can be demonstrated first by the reduction
in viscosity and next of the increase in volume of sputa. However,
the decrease in amount of freeze-dried substance is not always
in accord with the reduction viscosity. |
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