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WAM Essentials, Inc.
Systemic Enzyme Therapy
... Allowing You to Live Your Passion!™ |
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Effect of the proteolytic enzyme serrapeptase in patients with
chronic airway disease.
Nakamura S, Hashimoto Y, Mikami M, Yamanaka E, Soma T, Hino
M, Azuma A, Kudoh S.
Respirology. 2003 Sep;8(3):316-20.
Department of Respiratory Medicine, Tokyo Metropolitan Hiroo
General Hospital, Japan. hb16104@alto.ocn.ne.jp |
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Abstract: |
OBJECTIVES: The proteolytic enzyme serrapeptase
(SER) is widely used in clinical practice in Japan. We investigated
the effect of SER on sputum properties and symptoms in patients
with chronic airway diseases.
METHODS: This study was an open-labelled
trial with a non-treatment control group. Patients were
randomly assigned to oral treatment with (n = 15) and without
(n = 14) SER 30 mg/day for 4 weeks. Patients collected sputum
samples for about 4 h in the morning on the day the trial
began and 4 weeks later. We measured the amount of sputum
by weighing. Part of each sputum sample was weighed and then
completely dried and reweighed. The percentage solid component,
viscosity and elasticity of the sputum were measured. Mucociliary
transportability index was measured using ciliated bovine
trachea ex vivo. Sputum smears were also prepared to count
sputum neutrophils. Patients' symptoms were assessed by a
questionnaire that used a visual analogue scale.
RESULTS:
After 4 weeks of SER treatment, sputum weight in the morning,
percentage solid component, viscosity and elasticity of
sputum, sputum neutrophil count, frequency of coughing and
frequency of expectoration significantly decreased. The mean
mucociliary transportability index increased from 13.3 +/-
1.8 to 24.4 +/- 2.5 (P = 0.0103).
CONCLUSIONS: SER may exert
a beneficial effect on mucus clearance by reducing neutrophil
numbers and altering the viscoelasticity of sputum in patients
with chronic airway diseases. |
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None of the material contained herein may be reproduced without
the prior written consent of WAM Essentials, Inc. |
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