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Systemic Enzyme Study Abstracts by Medical Specialty

Absorption

Transport of Proteolytic Enzymes Across Caco-2 Cell Monolayers
Intestinal absorption of serrapeptase (TSP) in rats.
 

Bacteriology

  Proteolytic enzymes: a new treatment strategy for prosthetic infections?
Studies on the distributions of antibiotics in the oral tissues: Experimental staphylococcal infection in rats, and effect of serratiopeptidase on the distributions of antibiotics (author's transl)

Blood and Lymph

Lipoprotein Immune Complexes as Markers of Artherosclerosis
  Proteolytic enzymes in prevention and treatment of lymphatic oedema of arm after axillary dissection or radiotherapy
  Lymphedema
  Lymphoedema and its therapeutic options
  Selective modulation of cell adhesion molecules on lymphocytes by bromelain protease 5
  Non-extremity lymphedema following axilla dissection and radiotherapy
  Pharmacotherapy of lymphedema of the arm after axilla exenteration and radiotherapy
  Proteolytic enzymes in prevention and treatment of lymphatic oedema of arm after axillary dissection or radiotherapy
  Cytokine synthesis in human peripheral blood mononuclear cells after oral administration of polyenzyme preparations

Cancer Therapy

Proteinase administration reduces growth of human breast and pancreatic cancer in nude mice and diminishes expression of some tumorigenesis biomarkers
Pharmacoprophylaxis of the arm secondary lymphedema development after axilla exenteration and radiotherapy
Comparison of media conditions to expand TIL-derived T-cell lines from patients with peritoneal carcinomatosis including serum free, rIFN-g and polyenzyme preparation
Augmentation by serrapeptase of tissue permeation by cefotiam
Oral therapy with proteolytic enzymes decreases excessive TGF-b levels in human blood
Bromelain proteases suppress growth, invasion and lung metastasis of B16F10 mouse melanoma cells
Bromelain proteinase F9 augments human lymphocyte-mediated growth inhibition of various tumor cells in vitro
Bromelain proteinases modulate the CD44 expression on human Molt 4/8 leukemia and SK-Mel 28 melanoma cells in vitro
Comparison of media conditions to expand TIL-derived T-cell lines from patients with peritoneal carcinomatosis including serum free, rIFN-g and polyenzyme preparation
Proteolytic Enzymes Modulate the Adhesion Molecule CD44 on Malignant Cells in Vitro

Cardiology

Dental

Volumetric verification of edema protection with Serrapeptase after third molar osteotomy
 

Dermatology

Orally administered proteases in aesthetic surgery

Ear, Nose and Throat

A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling.
Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease.
The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus.
A technique for quantitative cytology of nasal secretions.
Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo.
Effect of expectorants on relaxation behavior of sputum viscoelasticity in vivo.
A new method for evaluating mucolytic expectorant activity and its application. II. Application to two proteolytic enzymes, serratiopeptidase and seaprose.
Effects of orally administered drugs on dynamic viscoelasticity of human nasal mucus.

General Research

Intestinal absorption of serrapeptase (TSP) in rats.

Immunology

  What is the Mechanism of "Immunonormalizing" Effects of Proteolytic Enzyme Combination in the Systemic Enzyme Therapy?
Beneficial effect of proteases on allograft arteriosclerosis in a rat aortic model
Bromelain treatment of human T cells removes CD44, CD45RA, E2/MIC2, CD6, CD7, CD8, and Leu 8/LAM1 surface molecules and markedly enhances CD2-mediated T cell activation
  Immunomodulation by a2-macroglobulin and a2-macroglobulin-proteinase complexes: the effect on the human T lymphocyte response
  Cytokine synthesis in human peripheral blood mononuclear cells after oral administration of polyenzyme preparations
  Interactions between cytokines and a2-macroglobulin
  Oral therapy with proteolytic enzymes decreases excessive TGF-b levels in human blood
  Bromelain treatment of human T cells removes CD44, CD45RA, E2/MIC2, CD6, CD7, CD8, and Leu 8/LAM1 surface molecules and markedly enhances CD2-mediated T cell activation

Inflammation

  How Systemic Enzymes fight Inflammation
  ExCLzyme-EN® Clinical Efficacy
  Anti-inflammatory and analgesic activity of ExCLzyme-EN®
  Plant cysteine proteases - new supportive agents in Alzheimer disease therapy?
Low-dose chymotrypsin treatment inhibits neutrophil migration into sites of inflammation in vivo: effects on Mac-1 and MEL-14 adhesion protein expression and function
A preliminary trial of serratiopeptidase in patients with carpal tunnel syndrome.
  Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo.
  Treatment with non-steroidal anti-inflammatory drugs in patients with amicrobial chronic prostato-vesiculitis: transrectal ultrasound and seminal findings
  Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with serrapeptase-- a prospective study
  Clinical study of the efficacy of and tolerance to seaprose S in inflammatory venous disease. Controlled study versus serratio-peptidase
  Volumetric verification of edema protection with Serrapeptase after third molar osteotomy

Nephrology / Urology / Renal Fibrosis

  Renal fibrosis: Role of impaired protein degradation and potential therapeutic strategies
  Amelioration of the development of chronic renal failure by systemic enzyme treatment in the rat model of 5/6 nephrectomy
  Effects of Protease Therapy in the Remnant Kidney model of Progressive Renal Failure
  Enzymolysis of glomerular immune deposits in vivo with dextranase/protease ameliorates proteinuria, hematuria, and mesangial proliferation in murine experimental IgA nephropathy
  Enzyme therapy of experimental glomerulonephritis
Renal fibrosis: Role of impaired protein degradation and potential therapeutic strategies
Treatment with non-steroidal anti-inflammatory drugs in patients with amicrobial chronic prostato-vesiculitis: transrectal ultrasound and seminal findings

Neurology

  Evaluation of perspective agents for Alzheimer disease therapy by means of in vitro test with beta amyloid protein
  Interaction Between Proteases and Blood-Brain Barrier: Possible Sequellae for Clinical Praxis
Beta amyloid protein and plant cysteine proteinases influence the (3H)hemicholinium-3 binding site in vitro in rat hippocampus

OBGYN and Pregnancy

Immunomodulation in the treatment of reproduction disturbances
Bromelain proteases as immunomodulators for therapy of mammary tumors
Influence of Bromelain on Penetration of Antibiotics in Uterus, Salpinx and Ovary
  Therapy of adnexitis - enhancement of the basic antibiotic therapy with hydrolytic enzymes
  Treatment of fibrocystic mastopathy with hydrolytic enzymes
Enzyme therapy - a method of immune therapy for immunologically caused habitual abortions

Orthopedics

Treatment of collagen-induced arthritis by proteolytic enzymes.
Efficacy and safety of an oral enzyme conbination compared to NSAIDs in activated degenerative rheumatic joint disease
Efficacy and tolerance of oral hydrolytic enzymes in ankylosing spondylitis as compared with indomethacin: a controlled double-blind prospective clinical trial
Short-Term treatment of painful Osteoarthritis of the Knee with Oral enzymes
Evidence of the efficacy of an enzyme combination preparation using the method of artificial hematomas in combination with a pressure meter

Pulmonology

Enteral administration of proteinase mixture inhibits development of radiation pneumonitis and lung fibrosis in rats
Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease.
Effect of expectorants on relaxation behavior of sputum viscoelasticity in vivo.
A new method for evaluating mucolytic expectorant activity and its application. II. Application to two proteolytic enzymes, serratiopeptidase and seaprose.

Rheumatology

  Efficacy and tolerance of oral hydrolytic enzymes in ankylosing spondylitis as compared with indomethacin: a controlled double-blind prospective clinical trial
  Cost of treating arthritis and NSAID-related gastrointestinal side-effects
  Efficacy and safety of an oral enzyme combination compared to NSAIDs in activated degenerative rheumatic joint disease
  Treatment of collagen-induced arthritis by proteolytic enzymes. Immunomodulatory and disease-modifying effects
 

Sports Medicine

  Physical activity and immune system. Systemic enzyme therapy in prevention and treatment

Transplants and Grafts

  Beneficial effect of proteases on allograft arteriosclerosis in a rat aortic model

Trauma and Surgery

  A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling.
  Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with serrapeptase-- a prospective study
Augmentation by serrapeptase of tissue permeation by cefotiam

Virology

Oral therapy with proteolytic enzymes decreases excessive TGF-b levels in human blood

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