| |
WAM Essentials, Inc.
Systemic Enzyme Therapy
... Allowing You to Live Your Passion!™ |
|
|
|
|
|
|
|
|
Efficacy and
safety of an oral enzyme combination compared to NSAIDs in
activated degenerative rheumatic joint disease
Bock P.1, Hanisch J.1, Schiess W.2, Stauder G.2, Wittenborg
A.3
1 IFAG, Institute for Medical Research and Statistics, Basle,
Switzerland.
2 Dept. Clinical Research, Mucos Pharma GmbH, Geretsried, Germany.
3 Center of Rheumatology Ruhrgebiet, Herne, Germany.
7th Interscience World Conference on Inflammation, Antirheumatics,
Analgesics, Immunomodulators, Geneva, Switzerland. 19-21
May 97,
published in Inter. Journal of Tissue Reactions Vol. XIX, No.
1/2, pp. 26-27, 1997 - Abst. 16, ISSN 0250-0868
149K/245 (19-04-2)
|
|
Abstract
Methods
Therapeutical data of 3028 not preselected patients with activated
degenerative rheumatic diseases from 379 medical offices were
evaluated using a reference-controlled, parallel group, multicentric,
retrolective analysis of therapeutic data (RetrospectTM) to
examine the efficacy and safety of oral enzymes (OE) as compared
to nonsteroidal anti-inflammatory drugs (NSAIDs). Identical
inclusion criteria were laid down in a written study protocol.
Data of 2137 patients treated with OE and of 891 patients treated
with NSAIDs were available for analysis. As primary test criterion
of efficacy the multivariate "Global-Symptom-Score" was
used, based on the changes in the scores of the cardinal symptoms,
and analysed using the non-parametric methods by Wei and Lachin.
Duration of disease and judgement of efficacy were secondary
efficacy criteria. For safety assessment unwanted drug reactions
and subjective judgements were compared. The sensitivity of
statistical test results to changes in the definition of the
populations was assessed by means of predefined subgroup analyses.
Results
Both therapy groups were well balanced (basic patient data,
initial severity of symptoms). Unwanted drug reactions were
reported in 4.3% and 31.8% in the OE and the NSAIDs group,
resp. Predominant adverse effects observed under the OE therapy
were mild gastrointestinal symptoms, lasting for less than
a week, while under NSAIDs moderate gastrointestinal symptoms,
lasting for 1-2 weeks, were the most frequent adverse effects.
The safety was rated to be "very high" for OE and
NSAIDs in 84% and 29%, resp. In all diagnostic strata the medical
rating of safety of OE was significantly (p<0.0001 ) and
distinctly higher than for NSAIDs. For all diagnostic strata,
both the Global-Symptom-Score and the medical judgement of
the efficacy were significantly superior (p<0.001 ) for
the OE group compared to the NSAIDs group. The duration of
therapy under OE was longer than under NSAIDs. |
|
|
|
|
|
Medical Disclaimer: We believe
that the role of nutrition is important to good health, however,
this web site is for informational purposes only and is not
intended to be a substitute for professional medical advice.
Our goal is to provide you, the customer, with the information
necessary for you to make important nutritional and self-help
decisions. We strongly suggest that you share any products
you decide to use with your health care professional for optimal
individual health benefits. Women who are planning on becoming
pregnant or who are pregnant should not take any supplements
without consulting their physician first. Information and statements
on this website regarding dietary supplements have not been
evaluated by the Food and Drug Administration, and are not
intended to diagnose, treat, cure, mitigate or prevent any
disease or health condition.
|
| |
|
© Copyright 2004 WAM Essentials,
Inc. All Rights Reserved.
None of the material contained herein may be reproduced without
the prior written consent of WAM Essentials, Inc. |
|
|
