| |
WAM Essentials, Inc.
Systemic Enzyme Therapy
... Allowing You to Live Your Passion!™ |
|
|
|
|
|
|
|
|
Treatment of
collagen-induced arthritis by proteolytic enzymes. Immunomodulatory
and disease-modifying effects
Chintalacharuvu S. R., Nagy N.U., Petersilge Ch. A., Abdul-Karim
F. W., and Emancipator S.N.
From the Institute of Pathology and the Department of Radiology,
Case Western Reserve University, Cleveland, OH USA
The Journal of Rheumatology 2001, Vol. 28, No. 9, pp 2049-2059
573 KA
|
|
Abstract
Objective
To investigate the efficacy of a novel therapy (proteases)
in an animal model of rheumatoid arthritis, and to gain insight
to the mechanisms of arthritogenesis.
Methods
We induced progressive arthritis in male DBA/1 mice by immunization
and boosting with Type II collagen; groups of mice were treated
orally twice daily with either ibuprofen or a commercial cocktail
of proteases, or left untreated. After two weeks, joints were
scored for clinical, radiographic and histologic changes. In
addition, serum levels of IgG anti-collagen II, the glycosylation
of circulating total and anti-collagen II IgG, and cytokine
production by lymphocytes isolated from lymph nodes were measured.
Results
Amelioration of joint inflammation and destruction, and accentuation
of a prototypical Th2 cytokine (IL-5) were similar in ibuprofen
and protease treatment groups. However, protease treatment
protects and preserves articular cartilage, normalizes the
sialylation of IgG and anti-collagen autoantibody and fully
restores Th1 (IFN-g) synthesis. Conclusion. Protease therapy
has anti-inflammatory efficacy in collagen-induced arthritis,
similar to ibuprofen. In addition, the immunomodulatory effects
of proteases, not seen with ibuprofen, may underlie a correction
of aberrant IgG glycosylation and/or contribute to the increased
capacity of protease to delay or forestall erosive and destructive
arthritis or ankylosis. Similar effects may apply to spontaneous
RA in patients. |
|
|
|
|
|
Medical Disclaimer: We believe
that the role of nutrition is important to good health, however,
this web site is for informational purposes only and is not
intended to be a substitute for professional medical advice.
Our goal is to provide you, the customer, with the information
necessary for you to make important nutritional and self-help
decisions. We strongly suggest that you share any products
you decide to use with your health care professional for optimal
individual health benefits. Women who are planning on becoming
pregnant or who are pregnant should not take any supplements
without consulting their physician first. Information and statements
on this website regarding dietary supplements have not been
evaluated by the Food and Drug Administration, and are not
intended to diagnose, treat, cure, mitigate or prevent any
disease or health condition.
|
| |
|
© Copyright 2004 WAM Essentials,
Inc. All Rights Reserved.
None of the material contained herein may be reproduced without
the prior written consent of WAM Essentials, Inc. |
|
|
