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Interaction Between Proteases and Blood-Brain Barrier: Possible Sequellae for Clinical Praxis

Š?astny F.1,2,3, Pliss L.3,4, Höschl C.1,2,3

1Psychiatrické centrum Praha
23. léka?ská fakulta Univerzity Karlovy
3Centrum neuropsychiatrických studií, Praha
4Department of Biochemistry, School of Medicine and Biomedical Sciences,
State University of New York at Buffalo, USA

Psychiatrie 2002, Vol. 6, No. 4, pp. 230–241 


Review introduces newer findings on the mode of action of proteases mostly used in clinical treatment. Systemic anti-inflammatory, anti-swelling, and anti-allergic effects (including the brain) can be supposed only if relevant proteases cross enteric and blood-brain barriers after oral administration, reach the system in detectable amount, and do not loose their enzymatic activity. Authors summarize findings supporting such a possibility, and point to limitations and further perspectives of the clinical use of proteolytic enzymes.

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