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[Treatment with non-steroidal anti-inflammatory
drugs in patients with amicrobial chronic prostato-vesiculitis:
transrectal ultrasound and seminal findings]
Vicari E, La Vignera S, Battiato C, Arancio A.
Minerva Urol Nefrol. 2005 Mar;57(1):53-9.
Sezione di Endocrinologia, Andrologia e Medicina Interna,
Dipartimento di Scienze Biomediche, Ospedale Garibaldi,
Universita degli Studi di Catania, Catania, Italy. acaloger@unict.it |
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Abstract: |
AIM: The aim of this paper was to evaluate
the efficacy (0= none; 3= fully) of the treatment with nonsteroidal
anti-inflammatory (NSAI) drugs on (a) gland post-inflammatory
echopattern, by transrectal ultrasound (TRUS); (b) seminal
cytologic (WBC concentration and spermiophagies) and (c) >2
physicochemical inflammatory parameters in patients with chronic
amicrobial prostato-vesiculitis (PV).
METHODS: Thirty-five
patients with PV received NSAI drugs in the following intermittently
steps (over a 3-month period): 1) Pygeum 100 mg twice a
day for 14 consecutive days per month; 2) flavoxate-propyphenazone
400 mg twice a day plus Serratiopeptidase 10 000 U twice
a day for the subsequent 14 days per month. All patients
underwent semen analysis and TRUS scans in the pre-treatment
and after 3 months of therapy.
RESULTS: The fully (a+b+c)
efficacy rate, through an improvement of TRUS prostatic
or vesicular echopattern in 37.1% and 22.8% respectively,
was higher than that registered with an improvement of only
1 or 2 endpoints. Altogether, the following TRUS findings
showed reductions (range 25-40%): prostate volume and hypochogenicity
(51.4%); vesicular antero-posterior diameter (APD) in the
43.5% and 28.6% of the uni- and bilateral PV respectively;
vesicular wall tickness (25%); unilateral vesicular honeycomb
aspect (36%). No efficacy, mainly related to immodified
TRUS prostatic or vesicular echopattern in 51.4% and 65.7%
respectively, was observed on: areas of prostatic hyperechogenicity;
peri-prostatic venous congestion; vesicular APD <7 mm or >21 mm (with honeycomb aspect).
CONCLUSIONS:
In PV patients, the treatment with NSAI compounds was
effective when it was enable to produce multiple positive
effects, mainly through TRUS changes. |
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