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WAM Essentials, Inc.
Systemic Enzyme Therapy
... Allowing You to Live Your Passion!™ |
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| Anti-inflammatory and analgesic
activity of ExCLzyme-EN®
S.L.Bodhankar, A.U.Burhan, V.M.Kale, S.Banerjee and S. Risbud
Bharati Vidyapeeth Deemed University, Poona College of Pharmacy,
Pune 411 038.
Raj Biotech Pvt. Ltd., Pune 411038
Group Companies of Specialty Enzymes and Biochemicals Co.,
Chino, California 91710 and Advanced Biochemicals Ltd. Thane
400601. |
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ExCLzyme-EN® (Group Companies of Specialty
Enzymes and Biochemicals Co., Chino, California 91710 and
Advanced Biochemicals Ltd. Thane 400601.) belongs to the
class of “Proteolytic enzymes”. The enzymes inhibit
release of pain inducing amines and facilitate drainage of
exudates thereby promoting tissue repair process. They break
down fibrin and inhibit the gathering of platelets around
the healing site and protect tissue from damaging. The
objective was to study anti-inflammatory and analgesic
activity of ExCLzyme-EN®.
Carrageenan induced hind paw edema method of Winter et al,
(1962) in rats was used. ExCLzyme-EN® (100 mg/kg
and 200 mg/kg, p.o.) showed a dose dependant inhibitory effect
(49.73 % and 52.41 % inhibition).
Acetic acid induced writhing method of Taber et al, (1969)
was used to study peripheral analgesic activity in mice. ExCLzyme-EN® (40 mg/kg and 80 mg/kg, p.o.) showed a significant and dose
dependant inhibitory effect (82.73 and 93.01% inhibition).
Carrageenan induced edema is biphasic mediated by release
of histamine and 5-hydroxytryptamine (5-HT) during first
hour, and kinine release up to 2 1/2 h. From 2 1/2 to 6 h
the mediator appears to be prostaglandin, release of which
is closely associated with migration of leukocytes into inflamed
site. ExCLzyme-EN® showed peak inhibitory effect at
3 h indicating inhibition of prostaglandin phase.
It is concluded that ExCLzyme-EN® posses significant anti-inflammatory
and peripheral analgesic activity. |
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| Table 1: |
Effect of Vehicle (Distilled water) / EXCLzyme™ EN
(50 mg/kg, 100 mg/kg and 200 mg/kg) on carrageenan induced
rat paw edema. |
| Table 2: |
Effect of EXCLzyme™-EN 100mg/kg and 200 mg/kg on
Freund's adjuvant induced arthritis in rats. |
| Table 3: |
Effect of EXCLzyme™-EN on Acetic acid induced writhing
in mice. |
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| Table 1: |
Effect of Vehicle (Distilled water), EXCLzyme™ EN,
Wobenzyme (both same dose; 200 mg/kg) on carrageenan induced
rat paw edema. |
| Table 2: |
Effect of EXCLzyme™ EN and
Wobenzyme (both same dose; 200 mg/kg) on Freund's adjuvant
induced arthritis in rats. |
| Table 3: |
Effect of EXCLzyme™-EN on Acetic acid induced writhing
in mice. |
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© Copyright 2004 WAM Essentials,
Inc. All Rights Reserved.
None of the material contained herein may be reproduced without
the prior written consent of WAM Essentials, Inc. |
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