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WAM Essentials, Inc.
Systemic Enzyme Therapy
... Allowing You to Live Your Passion!™ |
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| Effects of orally administered drugs on dynamic viscoelasticity
of human nasal mucus.
Majima Y, Hirata K, Takeuchi K, Hattori M, Sakakura Y.
Am Rev Respir Dis. 1990 Jan;141(1):79-83.
Department of Otorhinolaryngology, Mie University School
of Medicine, Tsu, Japan. |
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The effects of orally administered drugs on rheologic properties
of nasal mucus were investigated in adult chronic sinusitis
patients. The elastic modulus G' and the dynamic viscosity
eta' of nasal mucus were determined by an oscillating sphere
magnetic rheometer. Both G' and eta' values of the mucus
before drug administration were much higher than optimal
viscoelasticity for mucociliary transport. Norfloxacin, an
antibacterial agent, reduced the G' but not the eta' of nasal
mucus. Serratiopeptidase, a proteolytic enzyme, reduced eta'
but did not reduce G'. S-carboxymethylcysteine, a blocked
thiol derivative of cysteine, did not change either G' or
eta'. L-cysteine ethyl ester hydrochloride, a sulfhydryl
type of agent, reduced both G' and eta'. The results indicate
that some of the orally administered mucokinetic agents can
improve the abnormal rheologic properties of nasal mucus
in chronic sinusitis. |
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