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WAM Essentials, Inc.
Systemic Enzyme Therapy
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Effect of expectorants on relaxation behavior of sputum
viscoelasticity in vivo.
Author: Shimura S, Okubo T, Maeda S, Aoki T, Tomioka M,
Shindo Y, Takishima T, Umeya K.
Source: Biorheology. 1983;20(5):677-83.
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Abstract: |
We studied the effects of expectorants (mucolytic
agents) in vivo on the relaxation behavior of sputum viscoelasticity.
Seven female and thirty-three male patients (56.8 +/- 19.3
yrs, range: 21 to 82 years old) with a chronic pulmonary disease
except bronchial asthma were studied. They were randomly put
into the control group or a group which would be given oral
treatments with an expectorant for a week after a one week
washout period. The groups were as follows: Group I (n = 8),
control; Group II (n = 7), Bromhexine hydrochloride 24 mg per
day; Group III (n = 10), Ambroxol 90 mg per day; Group IV (n
= 9) alpha - Chymotrypsin buccle 100 ch.u. per day; Group V
(n = 6), Serratiopeptidase 30 mg per day. In Groups IV & V,
frequency dependence of sputum viscoelasticity at the range
of omega = 10(-3) to 10(0) rad.sec-1 were clearly changed after
the treatments, and the magnitude of the relaxation and its
main relaxation time were significantly increased. On the other
hand, in Groups I, II & III, no significant changes of
the frequency dependences were observed. These findings suggest
that proteolytic enzymes administered orally work on the molecular
structure of sputum, and break down their linkages between
subunits of the structure. |
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