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WAM Essentials, Inc.
Systemic Enzyme Therapy
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Bromelain proteinases modulate the
CD44 expression on human Molt 4/8 leukemia and SK-Mel 28
melanoma cells in vitro
Harrach T.1, Gebauer
F.2, Eckert K.1,
Kunze R.2 and Maurer
H.R.1
1 Institut für Pharmazie, Abteilung Pharmazeutische
Biochemie, Freie Universität Berlin, D-12169 Berlin
2 IMTOX GmbH, D-13355, Gustav-Meyer-Allee 25,
Berlin, Germany
Int. J. Oncol. 1994, No. 5, pp. 485-488
SO 82 (2-02-1) |
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Abstract
CD44 cell surface proteins are involved in leukocyte binding
to endothelium and the metastatic spread of tumor cells.
Using flow cytometric analysis (FCMA), we investigated the
effects of the proteases bromelain, papain, trypsin, and
chymotrypsin on the density of CD44 molecules present on
human leukemia Molt 4/8 cells. Bromelain was found to be
most active in reducing CD44 receptor density. In addition,
the effects of the purified bromelain proteinases F4 and
F9 were investigated. On Molt 4/8 cells crude bromelain and
F9, with the highest proteolytical activity, were found to
be most active in reducing CD44 receptor density with a half
maximal value of 1.9 mg/ml and 2.3 mg/ml, respectively. On
human SK-Mel 28 melanoma cells especially F9 showed a strong
effect, with a half maximal value of 1.5 mg/ml. The implications
of the findings are discussed with view of the reported antimetastatic
activity of orally administrated bromelain with respect to
CD44.
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