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Pharmacotherapy of lymphedema of the arm after axilla
exenteration and radiotherapy
Wald M., Prausová J.* and Adámek J.
Department of Surgery
* Department of Oncology
2nd Medical School, Charles University,
Prague, Czech Republic
XI International Congress of Senology, Cancun -(Mexico), May 13 – 18,
2000, lecture pp. 215-218
495 KA (2-06-1)
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Summary
Presented work summarizes a pharmacotherapy of secondary lymphedema
of the arm developing after axilla exenteration and/or radiotherapy.
It points out the key etiopathogenesis sites of the "circulus
vitiosus" of secondary lymphedema development and progression
and shows a relation between pharmacological effects of benzopyrones,
diuretics, systemically acting proteinases and lymphedema pathophysiology.
The authors conclude based on their own experience that the use
of diuretics in the treatment of lymphedema is mostly contraindicated.
Benzopyrones show mainly a supportive effect in physical therapy
of lymphedema and their main indication is a dynamic insufficiency
of lymphatic system at the venous system impairment. Authors consider
administration of systemically acting proteinases which have a
direct causal relation to the lymphedema pathophysiology. Proteinase
therapy of secondary lymphedema was successful in 70% of patients. |
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