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WAM Essentials, Inc.
Systemic Enzyme Therapy
... Allowing You to Live Your Passion!™ |
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Selective modulation of cell adhesion molecules on lymphocytes
by bromelain protease 5
Kleef R., Delohery T.M., Bovbjerg D.H.
Memorial Sloan-Kettering Cancer Center, New York, N.Y., USA
Pathobiology 1996, Vol. 64, pp. 339-346.
241 KA |
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Abstract
Human peripheral blood mononuclear cells from healthy donors were
treated ex vivo with the proteolytic enzyme bromelain and studied
by flow cytometry. Bromelain-treated lymphocytes exhibited 60-90%
reduced cell surface staining for CD44 and CD62-L molecules. While
the staining for molecules CD16, CD56 and CD49d was unaffected,
a moderate increase (10-40%) in expression of the b2-integrins
CD 11a-c was seen. This selective modulation of cell adhesion molecules
(CAM) was seen on T cells and NK cells, as well. The selective
modulation of CAM may help explain some of the clinical effects
observed after bromelain treatment in patients suffering from chronic
inflammatory disease, HIV and cancer.
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